THERAPEUTIC PLATFORM

“Transforming a human first, data-driven microbiome discovery platform to drug development for multiple diseases”

G-NiiB GenieBiome leverages one of the first and largest Asian human microbial data-driven approach to therapeutics development. Our expanding disease-specific microbial datasets compared with a comprehensive control microbial dataset provide a rich source for novel therapeutic candidates. We have the ability to develop novel consortia with beneficial functional and metabolic profiles, to target multiple human diseases.

Turning microbes into novel therapeutics

Our Targeted Microbiome Supplements

were derived utilizing large metagenomic microbial datasets and machine-learning approaches to deliver missing microbes and their biologically important functions to restore “dysbiosis” in conditions associated with it.

Our
Technology Breakthrough

Our unique Asian human microbiome database, advanced metagenomic sequencing technology and AI-driven data analysis platform enable us to analyse and develop unique, novel microbiome precision therapeutics. With our proprietary techniques, we have isolated over 20 novel live bacteria strains with therapeutically active functions.

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Evidence-based therapeutics solutions

Five unique microbiome formulas have been developed by using metagenomic sequencing data and proprietary AI and supported with data from clinical studies from the Faculty of Medicine, The Chinese University of Hong Kong.

Oral live microencapsulated bacteria for immunity- SIM01

Precise 3+3 Bifidobacteria and prebiotics formula with 10 patents

Replenishes beneficial microbes and enhances immunity

Two large-scale placebo-controlled, clinical studies have demonstrated SIM01’s efficacy¹,²

Hastened recovery and increased neutralising IgG in acute COVID-19 infections

Reduced adverse effects after SARS-CoV-2 vaccination

Reduced the relative risk of daily infections by 66%¹

Alleviated fatigue, difficult in concentration, memory loss, digestive problems and general unwellness in COVID-19 recoverees²

Improved skin quality, positive mood and sleep quality by an average of 100%¹

Increased colonization of beneficial bacteria and restored dysbiosis

Oral live microencapsulated bacteria for gut protection - SMT04

Precise live probiotics and prebiotics formula with 4 patents

Relieves gut problems and guards the gut against serious illness-inducing bacteria

Strengthens the gut barrier functions and enhances gut protection

Reduced colon-cancer related pathogenic bacteria (Fusobacteria etc) by 83%³

Oral live microencapsulated bacteria for children immunity - SIM03

Precise live probiotics and prebiotics with extra nutrition intensifiers

Relieves gut problems and guards the gut against serious illness-inducing bacteria

Develops a diverse rainbow immunity in children

Relieves sensitive skin and improves irritable physique

Improved symptoms in children with moderate-severe atopic dermatitis (based on validated SCORAD score) ⁴

Reduced sensitive skin areas and lesions by 38.9% (SCORAD) ⁴

Improved overall quality of life score (IDQOL & CDLQI) by 53% ⁴

Oral live microencapsulated bacteria for healthy skin

Precise live probiotics and prebiotics formula to replenish beneficial probiotics for healthy skin

Reduces redness, lesions and itchiness of the skin

Strengthens self-immunity, improves gut and skin health to lower sensitivity

Reduced eczematous area and severity by 23% in patients with atopic dermatitis⁵

Improved overall quality of life score (DLQI) by 37.5%⁵

Oral live microencapsulated bacteria for child mood

Precise live probiotics and prebiotics formula to replenish beneficial probiotics for children and adolescents

Promotes harmony of body, mind and soul

Fosters attention, improves whole person health and relieves worries and gastro-intestinal discomfort

Reduced anxiety symptoms level by 20% in children with autism spectrum disorder (ASD)⁶

Reduced sensory hypersensitivity symptoms level by 10% in ASD children⁶

Reduced functional abdominal pain disorder (FAPD) in 50% ASD children⁶

References

1

Wong, M. C. S., Zhang, L., Ching, J. Y. L., Mak, J. W. Y., Huang, J., Wang, S., Mok, C. K. P., Wong, A., Chiu, O. L., Fung, Y. T., Cheong, P. K., Tun, H. M., Ng, S. C., & Chan, F. K. L. (2023). Effects of Gut Microbiome Modulation on Reducing Adverse Health Outcomes among Elderly and Diabetes Patients during the COVID-19 Pandemic: A Randomised, Double-Blind, Placebo-Controlled Trial (IMPACT Study). Nutrients, 15(8), 1982. https://doi.org/10.3390/nu15081982.

2

Lau, R. I., Su, Q., Lau, I. S. F., Ching, J. Y. L., Wong, M. C. S., Lau, L. H. S., Tun, H. M., Mok, C. K. P., Chau, S. W. H., Tse, Y. K., Cheung, C. P., Li, M. K. T., Yeung, G. T. Y., Cheong, P. K., Chan, F. K. L., & Ng, S. C. (2023). A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (RECOVERY): a randomized, double-blind, placebo-controlled trial. The Lancet Infectious Diseases. Advance online publication. https://doi.org/10.1016/S1473-3099(23)00685-0.

3

Liang, J. Q., Zeng, Y., Lau, E. Y. T., Sun, Y., Huang, Y., Zhou, T., Xu, Z., Yu, J., Ng, S. C., & Chan, F. K. L. (2023). A Probiotic Formula for Modulation of Colorectal Cancer Risk via Reducing CRC-Associated Bacteria. Cells, 12(9), 1244. https://doi.org/10.3390/cells12091244.

4

Chan, O. M., Xu, W., Cheng, N. S., Leung, A. S. Y., Ching, J. Y. L., Fong, B. L. Y., Cheong, P. K., Zhang, L., Chan, F. K. L., Ng, S. C., & Leung, T. F. (2024). A novel infant microbiome formula (SIM03) improved eczema severity and quality of life in preschool children. Scientific reports, 14(1), 3168. https://doi.org/10.1038/s41598-024-53848-w

5

A pilot study of efficacy and safety of a microbiome immunity formula in adults with atopic eczema. The Faculty of Medicine, The Chinese University of Hong Kong, 2024. (Data on file).

6

"CUHK identifies novel gut microbiome biomarkers to facilitate diagnosis of autism spectrum disorders Pilot clinical study shows modulation of gut microbiome alleviates anxiety symptoms". The Faculty of Medicine, The Chinese University of Hong Kong, 11 July 2024. https://www.med.cuhk.edu.hk/press-releases/cuhk-identifies-novel-gut-microbiome-biomarkers-to-facilitate-diagnosis-of-autism-spectrum-disorders-pilot-clinical-study-shows-modulation-of-gut-microbiome-alleviates-anxiety-symptoms. Press Release.

“Transforming a human first, data-driven microbiome discovery platform to drug development for multiple diseases”

Turning microbes into novel therapeutics

Our Technology Breakthrough

Evidence-based therapeutics solutions

Our
Technology Breakthrough